In both cases (GdNCT and BNCT) it is very important to achieve levels of Gd-157 or B-10 concentration in tumor cells as high as possible in comparison with normal cells, where concentration of that agents should be minimal. Proposed researches in this fields will be mainly focused on the development of various forms of targeted drug containing Gd-157 or B-10 (nanoparticles, chelates, ligands).

Boron neutron capture is associated with production of high LET radiation (He and Li ions), that has very short range, equal to the dimensions of chromosome (less then 10 micrometers). As a result huge amount of unpreparable DNA damages are produced (mainly double strand DNA brakes).

B-10(n,g)B-11 reaction (physics)

B-10(n,g)B-11 reaction (biology)