New Project Developments
Universal radioisotope carrier
Sol-gel Y-90 microspheres for radioembolization
Gadolinium neutron capture is associated with production of gammas (energy range from 0,15 to 7 MeV). As well as short range Auger and IC electrons.
Boron neutron capture is associated with production of high LET radiation (He and Li ions), that has very short range, equal to the dimensions of chromosome (less then 10 micrometers).
There are two ways to produce neutron beams with required parameters (fluence, energy), suitable for NCT.
Development of a radiopharmaceutical drug based on samarium-153 and bio-degradable capsules for radioembolization of liver neoplasms
Development of a radiopharmaceutical drug based on encapsulated radium-223/radium-224 for intracavitary radiation therapy (treatment of peritoneal carcinomatosis (for stomach, colon, ovarian cancer) and pleura (for lung and breast cancer)
Development of a radiopharmaceutical drug based on a fibroblast activating factor inhibitor (FAPI) with improved pharmacokinetics for theranostics (PET-CT diagnostics and systemic radiation therapy):
Development includes: creation of an active drug substance, selection of the optimal composition of excipients, creation of a finished dosage form, automation of synthesis based on original (including cassette) synthesis modules, development of a drug specification, quality control methods and their validation, quality standard, preclinical studies of the efficacy and safety of drugs
Clinical studies of a radiopharmaceutical drug based on nanoantibodies to GITR and CTLA-4 receptors labeled with lutetium-177 for the treatment of generalized forms of kidney and bladder cancer (phase III studies). The same radiopharmaceutical drug labeled with 68Ga is offered as a diagnostic preparation (for PET-CT).
Method for automated synthesis of radiopharmaceuticals based on polymeric microparticles using a device for its implementation. Platform solution for application of radioisotopes.
Тheranostics and radiopharmaceutical drugs